cmpA

168

cortex morphogenic protein A, checkpoint protein, orchestrates spore coat and cortex morphogenesis

Locus: BSU_04785

Molecular weight: 4.00 kDa

Function: represses cortex assembly until the successful initiation of spore coat assembly

Product: cortex morphogenic protein A, adapter protein targeting SpoIVA for degradation by ClpXP upon spore envelope defects

Synonyms: cmpA

Genomic Context

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List of homologs in different organisms

Gene

Coordinates: 525,021 → 528,076

Phenotypes of a mutant

• quicker progressing through the sporulation cycle PubMed
• overexpression of CmpA results in heat-sensitive sporulation PubMed, this can be suppressed by mutations in ''clpP and clpX'' PubMed

The protein

Catalyzed reaction/ biological activity

• orchestrates spore coat and cortex assembly PubMed
• represses cortex assembly until spore coat assembly successfully initiates PubMed

Interactions

• ClpX-CmpA (for ClpX-ClpP-dependent degradation of SpoIVA) PubMed
• CmpA-SpoIVA (for ClpX-ClpP-dependent degradation of SpoIVA) PubMed

Localization

• surface of the developing spore, this depends on a functional SpoIVA PubMed

Expression and Regulation

Operons

• Genes: cmpA

  Description: PubMed

  Regulation

  • expressed in mother cell during sporulation (SigE, SpoIIID) PubMed

  Regulatory mechanism

  • SpoIIID: activation, PubMed, in spoIIID regulon

  Sigma factors

  • SigE: sigma factor, PubMed, in sigE regulon

References

Reviews

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Original Publications

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