dnaG
168
DNA primase, part of the replisome
Locus
BSU_25210
Molecular weight
68.62 kDa
Isoelectric point
6.71
Function
Product
DNA primase
Essential
yes
E.C.
2.7.7.-
Synonyms
dnaG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0358 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
The protein
Catalyzed reaction/ biological activity
synthesis of RNA primers that initiate leading and lagging strand DNA synthesis
required for bacteriophage SPP1 replication PubMed
Protein family
DNA primase family (single member, according to UniProt)
TOPRIM domain (aa 262-343) PubMed
Structure
1D0Q (PDB) (zinc binding domain, Geobacillus stearothermophilus)
1Z8S (PDB) (DnaB binding domain, AA 452-597, Geobacillus stearothermophilus)
Effectors of protein activity
the enzymatic activity is inhibited by (p)ppGpp during the stringent response, (p)ppGpp prevents DnaG from binding to replication forks and strongly inhibits primer extension PubMed
Cytoplasm (Homogeneous) PubMed
Expression and Regulation
Operons
Description
Regulation
enzymatic activity is inhibited by (p)ppGpp during the 'stringent response
Regulatory mechanism
Sigma factors
Additional information
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References
Reviews
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Original Publications
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Time of last update: 2025-01-22 16:50:17
Author of last update: Jstuelk