tatCD

168

component of the TatAD-TatCD twin-arginine translocase

Locus: BSU_02640

Molecular weight: 27.96 kDa

Isoelectric point: 9.34

Protein length: 242 aa

Gene length: 729 bp

Function: TAT protein secretion

Product: component of the twin-arginine translocation pathway

Essential: no

Synonyms: tatCD, ycbT

Genomic Context

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List of homologs in different organisms, belongs to COG0805 (Galperin et al., 2021)

Gene

Coordinates: 286,048  286,776

The protein

Catalyzed reaction/ biological activity

• translocation of PhoD PubMed

Protein family

• tatC family (with TatCY, according to UniProt)

Structure

• 4B4A (PDB) (from Aquifex aeolicus, 32% identity) PubMed
• P42252 (AlphaFold)

Paralogous protein(s)

• TatCY

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: phoD-tatAD-tatCD

  Description: PubMed

  Regulation

  • expressed under conditions of phosphate limitation (PhoP) PubMed

  Regulatory mechanism

  • PhoP: activation, PubMed, in phoP regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

  Additional information

  • expression of the operon depends on functional HemAT and CsbC PubMed

Biological materials

Mutant

• MGNA-C038 (ycbT::erm), available at the NBRP B. subtilis, Japan
• BKE02640 (tatCD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCAAAAAAGCCCTCCCT,  downstream forward: _UP4_AGGGAAGAAACAGCGGCGGC
• BKK02640 (tatCD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCAAAAAAGCCCTCCCT,  downstream forward: _UP4_AGGGAAGAAACAGCGGCGGC

Labs working on this gene/protein

• Jan Maarten van Dijl, University of Groningen, The Netherlands, Homepage

References

Reviews

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Original Publications

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