Difference between revisions of "SR4"
| (4 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
| − | * '''Description:''' antitoxin RNA, inhibits'' [[bsrG]]'' | + | * '''Description:''' antitoxin RNA, inhibits'' [[bsrG]]'' translation and causes destabilization of the ''[[bsrG]]'' mRNA <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 46: | Line 46: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=?&redirect=T ?] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
| Line 55: | Line 56: | ||
=== Additional information=== | === Additional information=== | ||
| + | |||
| + | =The RNA= | ||
| + | binds the ''[[bsrG]]'' mRNA and triggers its degradation {{PubMed|22229825}}, moreover SR4 inhibits ''[[bsrG]]'' translation {{PubMed|23969414}} | ||
=Expression and regulation= | =Expression and regulation= | ||
| Line 85: | Line 89: | ||
=References= | =References= | ||
| − | + | <pubmed> 23969414 22229825 26234942</pubmed> | |
| − | <pubmed></pubmed> | ||
[[Category:Small RNA]] | [[Category:Small RNA]] | ||
Latest revision as of 08:14, 4 August 2015
| Gene name | SR4 |
| Synonyms | |
| Essential | no |
| Product | antitoxin RNA |
| Function | inhibition of BsrG toxin expression |
| Gene length | 180 bp |
| Immediate neighbours | bsrG, yokL |
| Get the DNA sequence | |
| Genetic context File:BsrG context.gif This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
toxins, antitoxins and immunity against toxins, SPß prophage, ncRNA
This gene is a member of the following regulons
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
- cell lysis on agar plates PubMed
Database entries
- BsubCyc: ?
- DBTBS entry: no entry
- SubtiList entry: no entry
- Structure:
Additional information
The RNA
binds the bsrG mRNA and triggers its degradation PubMed, moreover SR4 inhibits bsrG translation PubMed
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
Labs working on this gene/RNA
Sabine Brantl, Jena, Germany
Your additional remarks
References
Natalie Jahn, Sabine Brantl, Henrik Strahl
Against the mainstream: the membrane-associated type I toxin BsrG from Bacillus subtilis interferes with cell envelope biosynthesis without increasing membrane permeability.
Mol Microbiol: 2015, 98(4);651-66
[PubMed:26234942]
[WorldCat.org]
[DOI]
(I p)
Natalie Jahn, Sabine Brantl
One antitoxin--two functions: SR4 controls toxin mRNA decay and translation.
Nucleic Acids Res: 2013, 41(21);9870-80
[PubMed:23969414]
[WorldCat.org]
[DOI]
(I p)
Natalie Jahn, Heike Preis, Christoph Wiedemann, Sabine Brantl
BsrG/SR4 from Bacillus subtilis--the first temperature-dependent type I toxin-antitoxin system.
Mol Microbiol: 2012, 83(3);579-98
[PubMed:22229825]
[WorldCat.org]
[DOI]
(I p)
