degU
168
two-component response regulator, regulation of degradative enzyme expression, genetic competence, biofilm formation, capsule biosynthesis (together with SwrA), non-phosphorylated DegU is required for swarming motility
Locus
BSU_35490
Molecular weight
25.72 kDa
Isoelectric point
5.6
Function
regulation of degradative enzymes, genetic competence, and other adaptive responses
Product
two-component response regulator
Essential
no
Synonyms
degU, sacU, iep
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2197 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,644,607 → 3,645,296
Phenotypes of a mutant
The protein
Catalyzed reaction/ biological activity
transcription activator and repressor (see DegU regulon)
DegU-P represses expression of the fla/che operon (''flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-flgD-flgE-fliL-fliM-fliY-cheY-fliO-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB'') in the absence of SwrAA/2, and switches to an activator of the operon in the presence of SwrAA/2 PubMed
Response regulatory domain (aa 5-121) (according to UniProt)
HTH luxR-type domain (aa 159-224) (according to UniProt)
Structure
4GVP (PDB) (VraR from Staphylococcus aureus, 35% identity) PubMed
Modification
Effectors of protein activity
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Description
Regulation
Regulatory mechanism
DegU: activation, in degU regulon
Sigma factors
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Biological materials
Mutant
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab
References
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Time of last update: 2024-12-23 13:31:51
Author of last update: Jstuelk