bceS

bceS
168

two-component sensor kinase, regulation of bceA-bceB in response to bacitracin, plectasin, mersacidin and actagardine

Locus
BSU_30390
Molecular weight
38.61 kDa
Isoelectric point
5.94
Protein length
Gene length
Function
resistance against toxic peptides
Product
two-component sensor kinase
Essential
no
Synonyms
bceS, ytsB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0642 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,112,190  3,113,194
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of BceR
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
two transmembrane segments, C-terminal histidine phosphotransferase domain
Histidine kinase domain (aa 121-326) (according to UniProt)
Structure
Modification
autophosphorylation on a His residue
Effectors of protein activity
binding of BceB in the absence of bacitracin inhibits BceS autophosphorylation PubMed
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
Description
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bceRbceS

2025-04-04 07:43:31

ghost

80

0d9c5f5aba9cd37b65e502c54a394ddb9aea0053

3ED24B86B015CF9A9605EB84290EFCB74C536FCF

Biological materials
Mutant
GP3218 Δ(bceR-bceS-bceA-bceB)::cat, available in Jörg Stülke's lab
MGNA-A166 (ytsB::erm), available at the NBRP B. subtilis, Japan
BKE30390 (bceS::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_GCTCCGCCTTTCGATAAGGA,  downstream forward: _UP4_TGACGAAAATGTCACATGCT
BKK30390 (bceS::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_GCTCCGCCTTTCGATAAGGA,  downstream forward: _UP4_TGACGAAAATGTCACATGCT
References
Reviews
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Original Publications
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08F24CA21DC54031F6158AC0C772F3B520E5A849

Page visits: 3759

Time of last update: 2025-05-01 18:56:49

Author of last update: Jstuelk