Difference between revisions of "Elongasome"

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<big>'''A protein complex that catalyzes peptidoglycan biosynthesis and is thereby involved in maintaining [[cell shape]]'''</big>  
 
<big>'''A protein complex that catalyzes peptidoglycan biosynthesis and is thereby involved in maintaining [[cell shape]]'''</big>  
  
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==Complex members==
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* cell wall biosynthetic enzymes at the outer side of the membrane: [[penicillin-binding proteins]] ([[PbpA]], [[PbpH]], perhaps also [[PbpC]], [[DacC]], [[PbpI]])
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* transmembrane proteins: [[MreC]], [[MreD]], [[RodA]], [[RodZ]], they couple the cytosolic actin-like proteins to the extracellular peptidoglycan-synthesizing machinery
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* actin-like proteins at the inner surface of the membrane: [[MreB]], [[MreBH]], [[Mbl]], the polymers control/restrict the mobility of the cell wall elongation enzyme complex
  
 
==Related pages==
 
==Related pages==
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* [[cell wall synthesis]]
 
* [[cell wall synthesis]]
 
* [http://subtiwiki.uni-goettingen.de/pathways/cellwall.html Cell wall synthesis in SubtiPathways]
 
* [http://subtiwiki.uni-goettingen.de/pathways/cellwall.html Cell wall synthesis in SubtiPathways]
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==Labs working on the complex==
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* [[Rut Carballido-Lopez]], Jouy-en-Josas
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* [[Jeff Errington]], Newcastle upon Tyne
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* [[David Rudner]], New York
  
 
==Important publications==
 
==Important publications==
* [http://www.ncbi.nlm.nih.gov/pubmed/21636744 Domínguez-Escobar ''et al''.] from [[Rut Carballido-Lopez]]' lab and [http://www.ncbi.nlm.nih.gov/pubmed/21636745 Garner ''et al''.] report that movement of actin-like filaments is driven by the peptidoglycan elongation machinery. Both papers suggest that the [[MreB]]-like filaments serve to restrict the mobility of the peptidoglycan synthesizing machinery<br/>
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<pubmed>21636744 21636745 23848140 21725336 24094808 26029191</pubmed>
* '''Relevant ''Subti''Wiki pages:''' [[Rut Carballido-Lopez]], [[David Rudner]], [[MreB]], [[MreBH]], [[Mbl]], [[MreC]], [[MreD]], [[PbpA]], [[RodA]], [[RodZ]], [[penicillin-binding proteins]], [[cell shape]], [[cell wall synthesis]]
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<pubmed>21636744 21636745</pubmed>
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==Back to [[SubtInteract]]==
* A comment on these papers:
 
<pubmed> 21725336 </pubmed>
 

Latest revision as of 15:33, 7 July 2015

A protein complex that catalyzes peptidoglycan biosynthesis and is thereby involved in maintaining cell shape

Complex members

  • cell wall biosynthetic enzymes at the outer side of the membrane: penicillin-binding proteins (PbpA, PbpH, perhaps also PbpC, DacC, PbpI)
  • transmembrane proteins: MreC, MreD, RodA, RodZ, they couple the cytosolic actin-like proteins to the extracellular peptidoglycan-synthesizing machinery
  • actin-like proteins at the inner surface of the membrane: MreB, MreBH, Mbl, the polymers control/restrict the mobility of the cell wall elongation enzyme complex

Related pages

Labs working on the complex

Important publications


Back to SubtInteract