dapG

168

aspartokinase I (alpha and beta subunits)

Locus: BSU_16760

Molecular weight: 42.82 kDa

Isoelectric point: 5.71

Protein length: 404 aa

Gene length: 1215 bp

Function: biosynthesis of lysine and peptidoglycan

Product: aspartokinase I (alpha and beta subunits)

Essential: yes

E.C.: 2.7.2.4

Synonyms: dapG, lssD

Genomic Context

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List of homologs in different organisms, belongs to COG0527 (Galperin et al., 2021)

Gene

Coordinates: 1,747,123  1,748,337

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + L-aspartate --> 4-phospho-L-aspartate + ADP (according to UniProt)

Protein family

• aspartokinase family (with LysC and ThrD, according to UniProt)

Domains

• ACT domain (aa 344-404) (according to UniProt)

Structure

• 1SFT (PDB) (from Geobacillus stearothermophilus, 57% identity) PubMed
• Q04795 (AlphaFold)

Effectors of protein activity

• inhibited by diaminopimelic acid PubMed

Paralogous protein(s)

• LysC

Expression and Regulation

Operons

• Genes: asd-dapG-dapA

  Description: PubMed

  Sigma factors

  • SigK: sigma factor, PubMed, in sigK regulon
  • SigA: sigma factor, PubMed, in sigA regulon

• Genes: spoVFA-spoVFB-asd-dapG-dapA

  Description: PubMed

  Regulation

  • expressed late during sporulation in the mother cell (SigK) PubMed

  Sigma factors

  • SigK: sigma factor, PubMed, in sigK regulon

References

Reviews

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Original Publications

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