sigM
168
RNA polymerase ECF-type sigma factor SigM, required to prioritize carrier lipid (undecaprenyl-phosphate) utilization for peptidoglycan synthesis
Locus
BSU_09520
Molecular weight
19.26 kDa
Isoelectric point
6.77
Function
adaptation to inhibitors of peptidoglycan synthesis
Product
Essential
no
Synonyms
sigM, yhdM
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1595 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,029,577 1,030,068
Phenotypes of a mutant
The protein
Protein family
Sigma-70 factor family (according to UniProt)
ECF subfamily (according to UniProt)
Structure
Effectors of protein activity
antibiotics that block UndP recycling result in activation of SigM PubMed
SigM is released from the YhdL-YhdK complex upon undecaprenyl-phosphate limitation PubMed
Additional information
information on binding sites can be found in the PRODORIC2 database
Expression and Regulation
Operons
Biological materials
Mutant
BP129 (ΔsigM::aphA3), available in Fabian Commichau's lab
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
References
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Time of last update: 2024-12-20 07:46:37
Author of last update: Jstuelk