ypnP

168

putative damage inducible, Na+ driven multidrug efflux pump

Locus: BSU_21710

Molecular weight: 48.31 kDa

Isoelectric point: 10.05

Protein length: 445 aa

Gene length: 1338 bp

Function: unknown

Product: putative damage inducible, Na+ driven multidrug efflux pump

Essential: no

Synonyms: ypnP, dinF

Genomic Context

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List of homologs in different organisms, belongs to COG0534 (Galperin et al., 2021)

Gene

Coordinates: 2,288,669 → 2,290,006

The protein

Protein family

• MOP exporter family
• multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family (according to UniProt)

Structure

• 3VVO (PDB) (MATE multidrug exporter from Pyrococcus furiosus, 25% identity) PubMed
• P54181 (AlphaFold)

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: ypnP

  Description: (according to DBTBS) null

Biological materials

Mutant

• MGNA-A890 (ypnP::erm), available at the NBRP B. subtilis, Japan
• BKE21710 (ΔypnP::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTTTTCTCCTTGTGTTC,  downstream forward: _UP4_TAAGTGAAGCACTGCGAAAA
• BKK21710 (ΔypnP::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTTTTCTCCTTGTGTTC,  downstream forward: _UP4_TAAGTGAAGCACTGCGAAAA

References

Research papers

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