proG

proG
168

1-pyrroline-5-carboxylate dehydrogenase

Locus
BSU_12910
Molecular weight
30.05 kDa
Isoelectric point
4.91
Protein length
Gene length
Function
biosynthesis of proline
Product
1-pyrroline-5-carboxylate dehydrogenase
Essential
no
E.C.
1.5.1.2
Synonyms
proG, ykeA, yzcA

Genomic Context

List of homologs in different organisms, belongs to COG0345 (Galperin et al., 2021)

Gene
Coordinates
1,359,454  1,360,272
The protein
Catalyzed reaction/ biological activity
1-pyrroline-5-carboxylate + NADPH + H+ --> L-proline + NADP+ PubMed
L-proline + NADP+ --> 1-pyrroline-5-carboxylate + 2 H+ + NADPH (according to UniProt)
L-proline + NAD+ --> 1-pyrroline-5-carboxylate + 2 H+ + NADH (according to UniProt)
Protein family
NADPH PubMed
Structure
Effectors of protein activity
feedback-inhibited by proline PubMed
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
Description
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proG

2025-04-30 13:23:30

ghost

84

9563c62cb2cad4c9ca6a9ab4e852ff9e03d4e54e

B0D5771A0099742E0C49412813CA2447B0B2EC65

Biological materials
Mutant
MGNA-B308 (ykeA::erm), available at the NBRP B. subtilis, Japan
BKE12910 (proG::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATCGACTCAGTCCTTTCAT,  downstream forward: _UP4_TGAATCCTTGAAAGAGGATT
BKK12910 (proG::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATCGACTCAGTCCTTTCAT,  downstream forward: _UP4_TGAATCCTTGAAAGAGGATT
GP3728 (proG::tet trpC2) available in the Stülke lab
GP3741 (proG::aphA3 trpC2) available in the Stülke lab
Expression vectors
pGP3791: IPTG inducible expression, purification in E. coli with N-terminal His-tag, in pWH844, available in Jörg Stülke's lab
pGP3863: expression of Strep-proG by pGP380 in B. subtilis suitable for SPINE, available in Jörg Stülke's lab
References
Reviews
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Original Publications
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63AFCEE5DEA6B2604C02592C5FB52EDFAE68913E

Page visits: 2136

Time of last update: 2025-05-01 01:32:30

Author of last update: Robert.warneke