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Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!

Contact: General Microbiology, University of Göttingen, send mail

Upcoming events:

• The BACELL meeting 2015, organized by Leendert Hamoen will take place from April 14 to 15 in Amsterdam, The Netherlands. Website, Contact
• The International Conference on Metabolic Engineering, organized by Ivan Mijakovic and Leendert Hamoen will take place from April 16 to 17 in Amsterdam, The Netherlands. Website, Contact
• The 8th International Conference on Gram-positive Microorganisms (18th International Conference on Bacilli) in Montecatini Terme, organized by Marta Perego will take place from June 21 to 25. Conference website
• Past conferences

New: Subtiwiki is now on Facebook - please give it a +1!

Now online: A new description of SubtiWiki and its acompanying modules in the 2014 Database issue of Nucleic Acids Research

Raphael H Michna, Fabian M Commichau, Dominik Tödter, Christopher P Zschiedrich, Jörg Stülke
SubtiWiki-a database for the model organism Bacillus subtilis that links pathway, interaction and expression information.
Nucleic Acids Res: 2014, 42(Database issue);D692-8
[PubMed:24178028] [WorldCat.org] [DOI] (I p)

Paper of the month: March 2015

• In Bacillus subtilis, nitrogen acquisition is controlled by protein-protein interactions. Regulation is brought about by interactions of the trigger enzymes glutamine synthetase with the transcription factors TnrA and GlnR to inhibit or trigger their DNA-binding activity, respectively, and by the PII protein NrgB that also interacts with TnrA. Now, Schumacher et al. have solved the structures of several complexes involved in nitrogen sensing. The results unravel so far unprecendented mechanisms for metabolic reprogramming of the cell in response to nitrogen availability.
• Relevant SubtiWiki pages: GlnA, trigger enzymes, TnrA, GlnR, NrgB

Maria A Schumacher, Naga Babu Chinnam, Bonnie Cuthbert, Nam K Tonthat, Travis Whitfill
Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis.
Genes Dev: 2015, 29(4);451-64
[PubMed:25691471] [WorldCat.org] [DOI] (I p)

• Previous papers of the month

New procedure for account creation:

• Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
  
• Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!

News in SubtiWiki:

• August 2014: The first mobile application for SubtiWiki is now available for users of Android phones: Go for SubtiWiki in Google Play! IPhone users, please be patient! You will be served next! Click here to install!
• April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
• March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
• October 2012: the essential genes have been categorized
• September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
• August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
• April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
• April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
• December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways

Genes (examples)	Additional pages
spo0A	SubtiPathways
glnA	SubtInteract
rny	SubtiExpress
psdA	Regulons
pckA	methods
dnaA	metabolism
rnpA	categories
sigB	genome-wide analyses
ptkA	list of plasmids
mreC	labs working on Bacillus
ccpA	the people behind SubtiWiki
sr1	template

Publications describing SubtiWiki and SubtiPathways:

Raphael H Michna, Fabian M Commichau, Dominik Tödter, Christopher P Zschiedrich, Jörg Stülke
SubtiWiki-a database for the model organism Bacillus subtilis that links pathway, interaction and expression information.
Nucleic Acids Res: 2014, 42(Database issue);D692-8
[PubMed:24178028] [WorldCat.org] [DOI] (I p)

Ulrike Mäder, Arne G Schmeisky, Lope A Flórez, Jörg Stülke
SubtiWiki--a comprehensive community resource for the model organism Bacillus subtilis.
Nucleic Acids Res: 2012, 40(Database issue);D1278-87
[PubMed:22096228] [WorldCat.org] [DOI] (I p)

Lope A Flórez, Sebastian F Roppel, Arne G Schmeisky, Christoph R Lammers, Jörg Stülke
A community-curated consensual annotation that is continuously updated: the Bacillus subtilis centred wiki SubtiWiki.
Database (Oxford): 2009, 2009;bap012
[PubMed:20157485] [WorldCat.org] [DOI] (I p)

Christoph R Lammers, Lope A Flórez, Arne G Schmeisky, Sebastian F Roppel, Ulrike Mäder, Leendert Hamoen, Jörg Stülke
Connecting parts with processes: SubtiWiki and SubtiPathways integrate gene and pathway annotation for Bacillus subtilis.
Microbiology (Reading): 2010, 156(Pt 3);849-859
[PubMed:19959575] [WorldCat.org] [DOI] (I p)