gbsA

gbsA
168

glycine betaine-aldehyde dehydrogenase, glycine betaine synthesis

Locus
BSU_31060
Molecular weight
53.50 kDa
Isoelectric point
4.71
Protein length
Gene length
Function
osmoprotection
Product
glycine betaine-aldehyde dehydrogenase
Essential
no
E.C.
1.2.1.8
Synonyms
gbsA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1012 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,185,092  3,186,564
The protein
Catalyzed reaction/ biological activity
betaine aldehyde + H2O + NAD+ --> betaine + 2 H+ + NADH (according to UniProt)
Protein family
aldehyde dehydrogenase family (according to UniProt)
Structure
4QTO (PDB) (from Staphylococcus aureus, 67% identity, 87% similarity)
Paralogous protein(s)
Expression and Regulation
Operons
Genes
Description
Regulation
induced by choline (GbsR) PubMed
Regulatory mechanism
GbsR: repression, (transcriptional roadblock) PubMed, in gbsR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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gbsAgbsB

2025-01-16 15:17:49

ghost

59

937063a9a54ed4e12875306102d73517e6ee5839

8CD6FD61ACBEF014C97BE839B61E435F9EC8941B

Biological materials
Mutant
1A1056 ( gbsA::kan), PubMed, available at BGSC
BKE31060 (gbsA::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATATAAGCCTCCTTGACGT,  downstream forward: _UP4_AATTCATAAGAGGGGGAGAT
BKK31060 (gbsA::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATATAAGCCTCCTTGACGT,  downstream forward: _UP4_AATTCATAAGAGGGGGAGAT
Labs working on this gene/protein
Erhard Bremer, University of Marburg, Germany homepage
References
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1ADC55F8E265AF86E29743C671CE1EA1BE7EB41E

Page visits: 4262

Time of last update: 2025-01-19 05:20:46

Author of last update: Jstuelk