spoIID
168

cell wall hydrolase (lytic transglycosylase), required for complete dissolution of the asymmetric septum and for ribosome translocation to the forespore

Locus

BSU_36750

Molecular weight

37.25 kDa

Isoelectric point

9.76

Protein length

343 aaSequenceBlast

Gene length

1032 bpSequenceBlast

Function

dissolution of the septal cell wall

Product

lytic transglycosylase

Essential

Synonyms

spoIID, spoIIC

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2385 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

3,776,722 3,777,753

The protein

Catalyzed reaction/ biological activity

degrades the glycan strands of the peptidoglycan into disaccharide units PubMed, enhances SpoIIP activity PubMed

required for proper localization of SpoIIQ (together with SpoIIP) PubMed

Structure

4RWR (PDB) (from B. anthracis, 54% identity, 74% similarity) PubMed

P07372 (AlphaFold)

Localization

cell membrane PubMed

the complex of SpoIID, SpoIIM, and SpoIIP localizes at the leading edge of the mother cell engulfing membrane and is essential and rate limiting for membrane migration PubMed

localization of the SpoIID-SpoIIM-SpoIIP complex to the septal membrane depends on SpoIIB PubMed

Expression and Regulation

Operons

Genes

spoIID

Description

PubMed

Regulation

expressed early during sporulation in the mother cell (SigE, SpoIIID) PubMed

repressed by Spo0A-P binding to a box downstream of the promoter PubMed

Regulatory mechanism

SpoIIID: repression, PubMed, in spoIIID regulon