prsA

168

lipoprotein, post-translocational folding of exported proteins (post-translocation molecular chaperone)

Locus: BSU_09950

Molecular weight: 32.36 kDa

Isoelectric point: 9.12

Protein length: 292 aa

Gene length: 879 bp

Function: protein folding

Product: post-translocation molecular chaperone

Essential: yes

E.C.: 5.2.1.8

Synonyms: prsA

Genomic Context

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List of homologs in different organisms, belongs to COG0760 (Galperin et al., 2021)

Gene

Coordinates: 1,070,364  1,071,242

Phenotypes of a mutant

• essential PubMed
• the mutant is viable in the presence of elevated concentrations of Mg²⁺ PubMed

The protein

Catalyzed reaction/ biological activity

• catalyses the post-translocational folding of exported proteins PubMed, required for folding of [[penicillin-binding proteins]] (PbpA, PbpB, PbpC, PbpD) PubMed
• [protein]-peptidylproline (ω=180) --> [protein]-peptidylproline (ω=0) (according to UniProt)

Protein family

• PrsA family (single member, according to UniProt)

Domains

• PpiC domain (aa 134-224) (according to UniProt)

Structure

• 1ZK6 (PDB)
• P24327 (AlphaFold)

Modification

• PrsA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure PubMed

Localization

• membrane associated (lipoprotein) PubMed
• distinct spots organized in a helical pattern along the cell membrane PubMed

Expression and Regulation

Operons

• Genes: prsA

  Description: PubMed

  Additional information

  • PrsA is subject to degradation by WprA and other extracellular proteases PubMed

References

Reviews

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Original Publications

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