prp

168

protein cysteine protease, required for N-terminal cleavage of Ribosomal protein L27

Locus: BSU_27950

Molecular weight: 12.16 kDa

Isoelectric point: 4.46

Protein length: 112 aa

Gene length: 339 bp

Function: maturation of Ribosomal protein L27

Product: Ribosomal protein L27 cysteine protease

Essential: yes

Synonyms: prp, ysxB

Genomic Context

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Categories containing this gene/protein

Information processing, Protein synthesis, modification and degradation, Translation, Ribosome assembly

Information processing, Protein synthesis, modification and degradation, Proteolysis, Additional proteins involved in proteolysis

Groups of genes, Essential genes

List of homologs in different organisms, belongs to COG2868 (Galperin et al., 2021)

This gene is a member of the following regulons

Stringent response

Gene

Coordinates: 2,855,177 → 2,855,515

Phenotypes of a mutant

essential PubMed

The protein

Catalyzed reaction/ biological activity

N-terminal cleavage of Ribosomal protein L27 PubMed

Structure

2P92 (PDB) (the protein from S. aureus)
P26942 (AlphaFold)

Expression and Regulation

Operons

Genes: rplU-prp-rpmA

Description: PubMed

Regulation

Rel dependent downregulation (Class I) during stringent response PubMed
likely autorepression of the rplU→rpmA operon expression upon binding of excess of one ribosomal protein to the untranslated region of the rplU→rpmA mRNA PubMed

Regulatory mechanism

stringent response: negative regulation, in stringent response

Genes: spoIVFA-spoIVFB-rplU-prp-rpmA

Description: PubMed

Regulation

expressed early during sporulation in the mother cell (SigE, SpoIIID) PubMed

Additional information

the domains that inhibits SpoIVFB is cleaved off by CtpB (second cleavage) PubMed

References

Reviews

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Original Publications

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