prp

168

protein cysteine protease, required for N-terminal cleavage of Ribosomal protein L27

Locus: BSU_27950

Molecular weight: 12.16 kDa

Isoelectric point: 4.46

Protein length: 112 aa

Gene length: 339 bp

Function: maturation of Ribosomal protein L27

Product: Ribosomal protein L27 cysteine protease

Essential: yes

Synonyms: prp, ysxB

Genomic Context

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List of homologs in different organisms, belongs to COG2868 (Galperin et al., 2021)

Gene

Coordinates: 2,855,177 → 2,855,515

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• N-terminal cleavage of Ribosomal protein L27 PubMed

Structure

• 2P92 (PDB) (the protein from S. aureus)
• P26942 (AlphaFold)

Expression and Regulation

Operons

• Genes: rplU-prp-rpmA

  Description: PubMed

  Regulation

  • Rel dependent downregulation (Class I) during stringent response PubMed
  • likely autorepression of the rplU→rpmA operon expression upon binding of excess of one ribosomal protein to the untranslated region of the rplU→rpmA mRNA PubMed

  Regulatory mechanism

  • stringent response: negative regulation, in stringent response

• Genes: spoIVFA-spoIVFB-rplU-prp-rpmA

  Description: PubMed

  Regulation

  • expressed early during sporulation in the mother cell (SigE, SpoIIID) PubMed

  Additional information

  • the domains that inhibits SpoIVFB is cleaved off by CtpB (second cleavage) PubMed

References

Reviews

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Original Publications

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