htrC

168

similar to quality control membrane serine protease HtrA

Locus: BSU_40360

Molecular weight: 42.63 kDa

Isoelectric point: 5.32

Protein length: 400 aa

Gene length: 1203 bp

Function: unknown

Product: putative quality control membrane protease

Essential: no

Synonyms: htrC, yycK, yyxA

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0265 (Galperin et al., 2021)

Gene

Coordinates: 4,147,567  4,148,769

The protein

Protein family

• Peptidase S1C family (with HtrA and HtrB, according to UniProt)

Domains

• transmembrane helix (aa 22 - 42) (according to UniProt)
• PDZ domain (aa 295 - 392) (according to UniProt)

Structure

• 3QO6 (PDB) (from Arabidopsis thaliana, 37% identity) PubMed
• P39668 (AlphaFold)

Paralogous protein(s)

• HtrA

Localization

• inner spore membrane PubMed

Expression and Regulation

Operons

• Genes: htrC

  Description: PubMed

  Regulation

  • htrC transcript expressed during sporulation PubMed

  Sigma factors

  • SigG: sigma factor, PubMed, in sigG regulon

• Genes: walR-walK-walH-walI-walJ-htrC

  Description: PubMed

  Regulation

  • htrC transcript expressed during sporulation PubMed

Biological materials

Mutant

• MGNA-B823 (yycK::erm), available at the NBRP B. subtilis, Japan
• BKE40360 (htrC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTCCATCCTTTCCAAG,  downstream forward: _UP4_TAATAAAAGCAGTCTGGCAT
• BKK40360 (htrC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTCCATCCTTTCCAAG,  downstream forward: _UP4_TAATAAAAGCAGTCTGGCAT

References

Reviews

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Original Publications

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