sigA

168

RNA polymerase major sigma factor SigA

Locus: BSU_25200

Molecular weight: 42.80 kDa

Isoelectric point: 4.63

Protein length: 371 aa

Gene length: 1116 bp

Function: transcription

Product: RNA polymerase major sigma factor SigA

Essential: yes

Synonyms: sigA, rpoD, crsA

Genomic Context

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Categories containing this gene/protein

Information processing, RNA synthesis and degradation, Transcription, Sigma factors

Information processing, Regulation of gene expression, Sigma factors and their control, Sigma factors

Groups of genes, Essential genes

Groups of genes, Phosphoproteins, Phosphorylation on an Arg residue

List of homologs in different organisms, belongs to COG0568 (Galperin et al., 2021)

Gene

Coordinates: 2,600,214  2,601,329

Phenotypes of a mutant

essential PubMed

The protein

Protein family

Sigma-70 factor family (according to UniProt)

Structure

3IYD (PDB) (RNA polymerase from E. coli, 69% identity) PubMed
P06224 (AlphaFold)

Modification

phosphorylated on Arg-365 PubMed

Localization

cytoplasm PubMed

Expression and Regulation

Operons

Genes: sigA

Description: PubMed

Sigma factors

SigA: sigma factor, PubMed, in sigA regulon
SigH: sigma factor, PubMed, in sigH regulon
SigD: sigma factor, PubMed, in sigD regulon

Additional information

An antisense RNA is predicted for sigA PubMed

Genes: yqxD-dnaG-sigA

Description: PubMed

Regulation

enzymatic activity is inhibited by (p)ppGpp during the 'stringent response

Regulatory mechanism

Spo0A: repression, PubMed, in spo0A regulon

Sigma factors

SigA: sigma factor, PubMed, in sigA regulon
SigH: sigma factor, PubMed, in sigH regulon

Additional information

An antisense RNA is predicted for sigA PubMed

Labs working on this gene/protein

Charles Moran, Emory University, NC, USA homepage

References

Reviews

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Original Publications

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