csoR

168

transcription repressor of copZ-copA

Locus: BSU_33520

Molecular weight: 11.34 kDa

Isoelectric point: 7.3

Protein length: 101 aa

Gene length: 306 bp

Function: control of copper homeostasis

Product: transcription repressor

Essential: no

Synonyms: csoR, yvgZ

Genomic Context

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List of homologs in different organisms, belongs to COG1937 (Galperin et al., 2021)

Gene

Coordinates: 3,443,896  3,444,201

The protein

Protein family

• CsoR family (single member, according to UniProt)

Structure

• 4M1P (PDB) (from Geobacillus thermodenitrificans, 59% identity) PubMed
• O32222 (AlphaFold)

Effectors of protein activity

• Cu(I) ions cause release of CsoR from its operator sites

Expression and Regulation

Operons

• Genes: csoR-copZ-copA

  Description: PubMed

Biological materials

Mutant

• MGNA-B604 (yvgZ::erm), available at the NBRP B. subtilis, Japan
• BKE33520 (csoR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCGTACACCTCTGTTTA,  downstream forward: _UP4_TAAAGCGTTTTTTATTGTAA
• BKK33520 (csoR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCGTACACCTCTGTTTA,  downstream forward: _UP4_TAAAGCGTTTTTTATTGTAA

Labs working on this gene/protein

• John Helmann, Cornell University, USA Homepage
• Mohamed Marahiel, Marburg University, Germany homepage

References

Reviews

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Original Publications

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