ftsY

168

signal recognition particle

Locus: BSU_15950

Molecular weight: 36.19 kDa

Isoelectric point: 5.08

Protein length: 329 aa

Gene length: 990 bp

Function: protein secretion

Product: signal recognition particle

Essential: yes

Synonyms: ftsY, srb

Genomic Context

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List of homologs in different organisms, belongs to COG0552 (Galperin et al., 2021)

Gene

Coordinates: 1,670,140 → 1,671,129

Phenotypes of a mutant

• essential PubMed

The protein

Protein family

• GTP-binding SRP family (with FlhF and Ffh, according to UniProt)

Structure

• 2XXA (PDB) (complex Ffh-FtsY-Scr RNA, from E. coli) PubMed
• P51835 (AlphaFold)

Localization

• cell membrane, peripheral, via N-terminal lipid-binding domain PubMed

Expression and Regulation

Operons

• Genes: ftsY

  Description: PubMed

  Regulation

  • expressed during vegetative growth and during sporulation in the mother cell (SigK, GerE) PubMed

  Regulatory mechanism

  • GerE: activation, PubMed, in gerE regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon
  • SigK: sigma factor, PubMed, in sigK regulon

• Genes: rnc-smc-ftsY

  Description: PubMed

  Regulation

  • expressed during vegetative growth and during sporulation in the mother cell (SigK, GerE) PubMed

  Regulatory mechanism

  • stringent response: negative regulation, in stringent response

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

References

Reviews

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Original Publications

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