ftsW
168

SEDS family peptidoglycan glycosyltransferase, cell division protein, core member of the divisome

Locus

BSU_14850

Molecular weight

43.57 kDa

Isoelectric point

9.72

Protein length

403 aaSequenceBlast

Gene length

1212 bpSequenceBlast

Function

cell division

Product

SEDS family peptidoglycan glycosyltransferase

Essential

yes

Synonyms

ftsW, ylaO

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0772 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,552,899 1,554,110

Phenotypes of a mutant

essential PubMed

The protein

Catalyzed reaction/ biological activity

principal peptidoglycan glycosyltransferase of the divisome PubMed

[GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)]_(n)-diphospho-di-trans,octa-cis-undecaprenol + β-D-GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol --> [GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)]_(n+1)-diphospho-di-trans-octa-cis-undecaprenol + di-trans,octa-cis-undecaprenyl diphosphate + H⁺ (according to UniProt)

Protein family

SEDS proteins (shape, elongation, division, and sporulation) PubMed

SEDS family (with RodA and SpoVE, according to UniProt)

Structure

6BAR (PDB) (from Thermus thermophilus,corresponds to aa 97... 359 34% identity) PubMed

O07639 (AlphaFold)

Paralogous protein(s)

RodA, SpoVE

Localization

integral membrane protein

localizes to the division site PubMed

localization depends on FtsZ PubMed