ftsL

168

cell division protein (septum formation), controls together with EzrA dynamics of the FtsZ ring, part of the divisome

Locus: BSU_15150

Molecular weight: 12.93 kDa

Isoelectric point: 10.08

Protein length: 117 aa

Gene length: 354 bp

Function: Z-ring maturation and focusing septal peptidoglycan synthesis

Product: cell division protein, member of the divisome

Essential: yes

Synonyms: ftsL, ylxB, yllD

Genomic Context

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List of homologs in different organisms, belongs to COG4839 (Galperin et al., 2021)

Gene

Coordinates: 1,581,597  1,581,950

Phenotypes of a mutant

• essential PubMed
• depletion results in decondensation of the FtsZ ring and lethal filamentation PubMed

The protein

Protein family

• FtsL family (single member, according to UniProt)

Structure

• Q07867 (AlphaFold)

Effectors of protein activity

• degraded by RasP, stabilized against RasP cleavage by DivIC PubMed

Localization

• cell membrane (according to UniProt)
• localizes to the division site, this depends on FtsW PubMed

Expression and Regulation

Operons

• Genes: mraZ-rsmH-ftsL-pbpB

  Description: PubMed

  Regulation

  • constitutively expressed PubMed

Additional information

• FtsL is degraded by RasP PubMed

Biological materials

Mutant

• MGNA-B127 (ftsL::erm), available at the NBRP B. subtilis, Japan

FLAG-tag construct

• GP2004 ftsL-3xFLAG ermC (based on pGP1087), available in Jörg Stülke's lab

References

Reviews

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Original Publications

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