bmrR

168

transcriptional activator (MerR family) of the bmr-bmrR operon, general stress protein

Locus: BSU_24020

Molecular weight: 32.43 kDa

Isoelectric point: 5.19

Protein length: 278 aa

Gene length: 837 bp

Function: regulation of multidrug resistance

Product: transcriptional activator (MerR family)

Essential: no

Synonyms: bmrR

Genomic Context

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List of homologs in different organisms, belongs to COG4978 (Galperin et al., 2021)

Gene

Coordinates: 2,495,898  2,496,734

The protein

Protein family

• MerR family

Domains

• HTH merR-type domain (aa 5-75) (according to UniProt)

Structure

• 2BOW (PDB) (complex with effector),  1R8E (PDB) (complex with DNA),  1BOW (PDB)
• P39075 (AlphaFold)

Expression and Regulation

Operons

• Genes: bmr-bmrR

  Description: PubMed

  Regulation

  • ''bmrU'': induced by stress (SigB) PubMed

  Regulatory mechanism

  • BmrR: activation, PubMed, in bmrR regulon
  • Mta: activation, PubMed, in mta regulon

  Sigma factors

  • SigB: sigma factor, PubMed, in sigB regulon
  • SigA: sigma factor, PubMed, in sigA regulon

• Genes: bmrU-bmr-bmrR

  Description: PubMed

  Regulation

  • ''bmrU'': induced by stress (SigB) PubMed

  Sigma factors

  • SigB: sigma factor, PubMed, in sigB regulon

Biological materials

Mutant

• BKE24020 (bmrR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCCATCACTCCTTCTAT,  downstream forward: _UP4_TAATAAAGCATAGAAAAAGA
• BKK24020 (bmrR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCCATCACTCCTTCTAT,  downstream forward: _UP4_TAATAAAGCATAGAAAAAGA

Labs working on this gene/protein

• Richard Brennan, Houston, Texas, USA Homepage

References

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