Difference between revisions of "Main Page"
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| − | <big>'''Paper of the month: | + | <big>'''Paper of the month: June 2014'''</big> |
| − | * | + | * [[Transcription]] by [[RNA polymerase]] is interrupted by pauses that play diverse regulatory roles. However, the determinants of pauses ''in vivo'' and their distribution throughout the bacterial genome remain unknown. Using nascent transcript sequencing, [http://www.ncbi.nlm.nih.gov/pubmed/24789973 Larson et al.] identified a 16-nucleotide consensus pause sequence. The pauses result from [[RNA polymerase]]-nucleic acid interactions that inhibit next-nucleotide addition. The consensus sequence is enriched at [[translation]] start sites in Bacillus subtilis. |
| − | * '''Relevant ''Subti''Wiki pages:''' [[ | + | ** '''Relevant ''Subti''Wiki pages:''' [[RNA polymerase]], [[transcription]], [[translation]] |
| − | <pubmed> | + | <pubmed> 24789973 </pubmed> |
| + | * See a comment on this issue: | ||
| + | <pubmed> 24926002 </pubmed> | ||
* [[Previous papers of the month]] | * [[Previous papers of the month]] | ||
Revision as of 12:37, 19 June 2014
Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!
Contact: General Microbiology, University of Göttingen, send mail
Upcoming events:
- PTS 50 - The PTS celebrates 50 years of transport and regulation, organized by Josef Deutscher, Milton Saier and Jörg Stülke will take place from September 07 to 08 in Göttingen, Germany. website, Registration form, contact
- The 1st International Conference on Post-Translational Modifications in Bacteria, organized by Ivan Mijakovic, Christophe Grangeasse, Alan Kent Nielsen and Jörg Stülke will take place from September 09 to 10 in Göttingen, Germany. website, Registration form, contact
- Past conferences
New: Subtiwiki is now on Facebook - please give it a +1!
Now online: A new description of SubtiWiki and its acompanying modules in the 2014 Database issue of Nucleic Acids Research
Raphael H Michna, Fabian M Commichau, Dominik Tödter, Christopher P Zschiedrich, Jörg Stülke
SubtiWiki-a database for the model organism Bacillus subtilis that links pathway, interaction and expression information.
Nucleic Acids Res: 2014, 42(Database issue);D692-8
[PubMed:24178028]
[WorldCat.org]
[DOI]
(I p)
Paper of the month: June 2014
- Transcription by RNA polymerase is interrupted by pauses that play diverse regulatory roles. However, the determinants of pauses in vivo and their distribution throughout the bacterial genome remain unknown. Using nascent transcript sequencing, Larson et al. identified a 16-nucleotide consensus pause sequence. The pauses result from RNA polymerase-nucleic acid interactions that inhibit next-nucleotide addition. The consensus sequence is enriched at translation start sites in Bacillus subtilis.
- Relevant SubtiWiki pages: RNA polymerase, transcription, translation
Matthew H Larson, Rachel A Mooney, Jason M Peters, Tricia Windgassen, Dhananjaya Nayak, Carol A Gross, Steven M Block, William J Greenleaf, Robert Landick, Jonathan S Weissman
A pause sequence enriched at translation start sites drives transcription dynamics in vivo.
Science: 2014, 344(6187);1042-7
[PubMed:24789973]
[WorldCat.org]
[DOI]
(I p)
- See a comment on this issue:
Jeffrey W Roberts
Molecular biology. Molecular basis of transcription pausing.
Science: 2014, 344(6189);1226-7
[PubMed:24926002]
[WorldCat.org]
[DOI]
(I p)
New procedure for account creation:
- Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
- Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!
News in SubtiWiki:
- April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
- March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
- October 2012: the essential genes have been categorized
- September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
- August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
- April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
- April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
- December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways
| Genes (examples) | Additional pages |
| spo0A | SubtiPathways |
| glnA | SubtInteract |
| rny | SubtiExpress |
| psdA | Regulons |
| pckA | methods |
| dnaA | metabolism |
| rnpA | categories |
| sigB | genome-wide analyses |
| ptkA | list of plasmids |
| mreC | labs working on Bacillus |
| ccpA | the people behind SubtiWiki |
| sr1 | template |
Publications describing SubtiWiki and SubtiPathways:
