gerAB

gerAB
168

alanine sensor, germination response to alanine, triggers premature germination in response to morphological defects during sporulation

Locus
BSU_33060
Molecular weight
41.30 kDa
Isoelectric point
9.6
Protein length
Gene length
Function
germination response to alanine
Product
alanine sensor of the nutrient-gated GerAA-GerAB-GerAC ion channel
Essential
no
Synonyms
gerAB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5902 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,392,199  3,393,296
Phenotypes of a mutant
suppresses the defects of spoVV mutant spores PubMed
reduced germination in response to Li+ PubMed
The protein
Catalyzed reaction/ biological activity
the GerAA-GerAB-GerAC ion channel releases ions from the spore core in response to L-alanine to trigger Germination PubMed
triggers premature germination in response to morphological defects during sporulation PubMed
binding of Li+ to trigger germination PubMed
Protein family
Structure
Paralogous protein(s)
predicted to be an integral membrane protein with ten membrane-spanning helices PubMed
inner spore membrane PubMed
Expression and Regulation
Operons
Description
Regulation
expressed during sporulation in the forespore (SigF, SigG, SpoVT) PubMed
Regulatory mechanism
SpoVT: repression, PubMed, in spoVT regulon
Sigma factors
SigG: sigma factor, PubMed, in sigG regulon
SigF: sigma factor, PubMed, in sigF regulon
Additional information
1,100 molecules are present per spore PubMed
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gerAAgerAC

2025-06-04 13:25:47

ghost

134

0b30e2b65ff83889103eaceb2726933679280f16

FB9C2DA86BEDDEDF47C18987147D4007D840E75A

Biological materials
Mutant
BKE33060 (gerAB::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_AACAATAGAAATACCTTGAA,  downstream forward: _UP4_CTCAAGAGGAGGATTACAAC
BKK33060 (gerAB::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_AACAATAGAAATACCTTGAA,  downstream forward: _UP4_CTCAAGAGGAGGATTACAAC
References
Reviews
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Original Publications
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5FF739B8C087207039BB6DC293EE77F59337ED0B

Page visits: 3948

Time of last update: 2025-06-06 09:29:20

Author of last update: Jstuelk