Difference between revisions of "LutR"
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| − | * '''Description:''' repressor of the ''[[lutA]]-[[lutB]]-[[lutC]]'' operon <br/><br/> | + | * '''Description:''' transcriptional repressor ([[GntR family]]) of the ''[[lutA]]-[[lutB]]-[[lutC]]'' operon <br/><br/> |
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
Revision as of 17:51, 11 June 2014
- Description: transcriptional repressor (GntR family) of the lutA-lutB-lutC operon
| Gene name | lutR |
| Synonyms | yvfI |
| Essential | no |
| Product | transcriptional repressor, (GntR family) |
| Function | control of lactate utilization |
| Gene expression levels in SubtiExpress: lutR | |
| Metabolic function and regulation of this protein in SubtiPathways: lutR | |
| MW, pI | 19 kDa, 4.845 |
| Gene length, protein length | 525 bp, 175 aa |
| Immediate neighbours | lacR, lutP |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
utilization of specific carbon sources, transcription factors and their control
This gene is a member of the following regulons
The LutR regulon:
The gene
Basic information
- Locus tag: BSU34180
Phenotypes of a mutant
Database entries
- BsubCyc: BSU34180
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcriptional repressor of the lutA-lutB-lutC operon PubMed
- Protein family: GntR family of transcription factors
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: lactate acts as molecular inducer PubMed
Database entries
- BsubCyc: BSU34180
- Structure:
- UniProt: O07007
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: TEK1 lutR::Tn10::spc PubMed
- Expression vector: pQE60-lutR (His-tag) PubMed
- lacZ fusion: TEK7 lutR::lacZ::erm PubMed
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Richard Losick, Harvard Univ., Cambridge, USA homepage
Ayten Katatas, Istanbul Technical University, Istanbul, Turkey [3]
Your additional remarks
References
Öykü İrigül-Sönmez, Türkan E Köroğlu, Büşra Öztürk, Ákos T Kovács, Oscar P Kuipers, Ayten Yazgan-Karataş
In Bacillus subtilis LutR is part of the global complex regulatory network governing the adaptation to the transition from exponential growth to stationary phase.
Microbiology (Reading): 2014, 160(Pt 2);243-260
[PubMed:24196425]
[WorldCat.org]
[DOI]
(I p)
Yunrong Chai, Roberto Kolter, Richard Losick
A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formation.
J Bacteriol: 2009, 191(8);2423-30
[PubMed:19201793]
[WorldCat.org]
[DOI]
(I p)
Additional publications: PubMed
