deoR

168

transcriptional repressor of the dra-nupC-pdp operon

Locus: BSU_39430

Molecular weight: 35.10 kDa

Isoelectric point: 6

Protein length: 313 aa

Gene length: 942 bp

Function: regulation of deoxyribonucleotide utilization

Product: transcriptional repressor

Essential: no

Synonyms: deoR, yxxC

Genomic Context

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Categories containing this gene/protein

Metabolism, Nucleotide metabolism, Utilization of nucleotides

Information processing, Regulation of gene expression, Transcription factors and their control, Transcription factors/ other

List of homologs in different organisms, belongs to COG2390 (Galperin et al., 2021)

This gene is a member of the following regulons

DeoR regulon

Gene

Coordinates: 4,052,379 → 4,053,320

The protein

Catalyzed reaction/ biological activity

transcription repression of the dra-nupC-pdp operon

Protein family

SorC transcriptional regulatory family (with CggR, according to UniProt)

Domains

N-terminal DNA-binding domain PubMed
C-terminal effector binding domain PubMed

Structure

8R7Y (PDB) (complex with operator DNA) PubMed
4OQQ (PDB) (C-terminal effector binding domain) PubMed
7BHY (PDB) (complex of the DNA-binding domain with the operator DNA) PubMed
4OQP (C-terminal effector binding domain bound to the effector deoxyribose-5-P) PubMed
P39140 (AlphaFold)

Effectors of protein activity

deoxyribose-5-P acts as the molecular inducer PubMed

Expression and Regulation

Operons

Genes: deoR

Description: PubMed

Biological materials

Mutant

BKE39430 (ΔdeoR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCTGCACCTCCCTGTGG,  downstream forward: _UP4_TGACACGTTCAAACCTTTCA
BKK39430 (ΔdeoR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCTGCACCTCCCTGTGG,  downstream forward: _UP4_TGACACGTTCAAACCTTTCA

References

Reviews

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Original Publications

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