Difference between revisions of "AdaA"

From SubtiWiki
Jump to: navigation, search
(Reviews)
Line 139: Line 139:
 
=References=
 
=References=
 
==Reviews==
 
==Reviews==
<pubmed> 22933559 </pubmed>
+
<pubmed> 22933559 24810496 </pubmed>
 +
 
 
== Original publications ==
 
== Original publications ==
 
<pubmed>2120677,8376346, </pubmed>
 
<pubmed>2120677,8376346, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 15:48, 23 May 2014

  • Description: trigger enzyme: methylphosphotriester-DNA alkyltransferase/ transcriptional activator of the adaA-adaB operon

Gene name adaA
Synonyms
Essential no
Product trigger enzyme: methylphosphotriester-DNA alkyltransferase/
transcriptional activator of the adaAB operon
Function adaptive response to alkylative DNA damage
Gene expression levels in SubtiExpress: adaA
MW, pI 24 kDa, 9.185
Gene length, protein length 633 bp, 211 aa
Immediate neighbours alkA, adaB
Sequences Protein DNA DNA_with_flanks
Genetic context
AdaA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
AdaA expression.png















Categories containing this gene/protein

DNA repair/ recombination, transcription factors and their control, trigger enzyme, prophage 1

This gene is a member of the following regulons

AdaA regulon

The gene

Basic information

  • Locus tag: BSU01810

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Damian Mielecki, Elżbieta Grzesiuk
Ada response - a strategy for repair of alkylated DNA in bacteria.
FEMS Microbiol Lett: 2014, 355(1);1-11
[PubMed:24810496] [WorldCat.org] [DOI] (I p)

Justin S Lenhart, Jeremy W Schroeder, Brian W Walsh, Lyle A Simmons
DNA repair and genome maintenance in Bacillus subtilis.
Microbiol Mol Biol Rev: 2012, 76(3);530-64
[PubMed:22933559] [WorldCat.org] [DOI] (I p)


Original publications

F Morohoshi, K Hayashi, N Munkata
Bacillus subtilis alkA gene encoding inducible 3-methyladenine DNA glycosylase is adjacent to the ada operon.
J Bacteriol: 1993, 175(18);6010-7
[PubMed:8376346] [WorldCat.org] [DOI] (P p)

F Morohoshi, K Hayashi, N Munakata
Bacillus subtilis ada operon encodes two DNA alkyltransferases.
Nucleic Acids Res: 1990, 18(18);5473-80
[PubMed:2120677] [WorldCat.org] [DOI] (P p)