Difference between revisions of "BceB"
| Line 63: | Line 63: | ||
=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
| − | |||
=The protein= | =The protein= | ||
| Line 81: | Line 78: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| + | ** the activity of the [[BceA]]-[[BceB]] [[ABC transporter]] is inhibited by heptaprenyl pyrophosphate which accumulates in a ''[[ytpB]]'' mutant {{PubMed|24806199}} | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| Line 142: | Line 140: | ||
=References= | =References= | ||
| − | <pubmed>18394148,17905982,12890034,14651641,10092453, 14612242 21283517, 20606066 21078927 23687272 </pubmed> | + | <pubmed>18394148,17905982,12890034,14651641,10092453, 14612242 21283517, 20606066 21078927 23687272 24806199</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 13:50, 11 May 2014
- Description: ABC transporter (permease) for the export of bacitracin, plectasin, mersacidin and actagardine
| Gene name | bceB |
| Synonyms | ytsD |
| Essential | no |
| Product | bacitracin ABC transporter (permease) |
| Function | export of toxic peptides |
| Gene expression levels in SubtiExpress: bceB | |
| Interactions involving this protein in SubtInteract: BceB | |
| MW, pI | 72 kDa, 9.79 |
| Gene length, protein length | 1938 bp, 646 aa |
| Immediate neighbours | yttA, bceA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
ABC transporters, resistance against toxins/ antibiotics, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU30370
Phenotypes of a mutant
Database entries
- BsubCyc: BSU30370
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ABC-4 integral membrane protein family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- the activity of the BceA-BceB ABC transporter is inhibited by heptaprenyl pyrophosphate which accumulates in a ytpB mutant PubMed
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- BsubCyc: BSU30370
- Structure:
- UniProt: O34741
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Anthony W Kingston, Heng Zhao, Gregory M Cook, John D Helmann
Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: implications for the mechanism of resistance mediated by the BceAB transporter.
Mol Microbiol: 2014, 93(1);37-49
[PubMed:24806199]
[WorldCat.org]
[DOI]
(I p)
Felix Kallenberg, Sebastian Dintner, Roland Schmitz, Susanne Gebhard
Identification of regions important for resistance and signalling within the antimicrobial peptide transporter BceAB of Bacillus subtilis.
J Bacteriol: 2013, 195(14);3287-97
[PubMed:23687272]
[WorldCat.org]
[DOI]
(I p)
Stéphanie Coumes-Florens, Céline Brochier-Armanet, Annick Guiseppi, François Denizot, Maryline Foglino
A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system.
PLoS One: 2011, 6(1);e15951
[PubMed:21283517]
[WorldCat.org]
[DOI]
(I e)
Anna Staroń, Dora Elisabeth Finkeisen, Thorsten Mascher
Peptide antibiotic sensing and detoxification modules of Bacillus subtilis.
Antimicrob Agents Chemother: 2011, 55(2);515-25
[PubMed:21078927]
[WorldCat.org]
[DOI]
(I p)
Jing Ouyang, Xiao-Lin Tian, Jennifer Versey, Alexander Wishart, Yung-Hua Li
The BceABRS four-component system regulates the bacitracin-induced cell envelope stress response in Streptococcus mutans.
Antimicrob Agents Chemother: 2010, 54(9);3895-906
[PubMed:20606066]
[WorldCat.org]
[DOI]
(I p)
Eva Rietkötter, Diana Hoyer, Thorsten Mascher
Bacitracin sensing in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);768-85
[PubMed:18394148]
[WorldCat.org]
[DOI]
(I p)
Remi Bernard, Annick Guiseppi, Marc Chippaux, Maryline Foglino, François Denizot
Resistance to bacitracin in Bacillus subtilis: unexpected requirement of the BceAB ABC transporter in the control of expression of its own structural genes.
J Bacteriol: 2007, 189(23);8636-42
[PubMed:17905982]
[WorldCat.org]
[DOI]
(I p)
Thorsten Mascher, Neil G Margulis, Tao Wang, Rick W Ye, John D Helmann
Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon.
Mol Microbiol: 2003, 50(5);1591-604
[PubMed:14651641]
[WorldCat.org]
[DOI]
(P p)
Remi Bernard, Pascale Joseph, Annick Guiseppi, Marc Chippaux, François Denizot
YtsCD and YwoA, two independent systems that confer bacitracin resistance to Bacillus subtilis.
FEMS Microbiol Lett: 2003, 228(1);93-7
[PubMed:14612242]
[WorldCat.org]
[DOI]
(P p)
Reiko Ohki, Giyanto, Kozue Tateno, Waka Masuyama, Shigeki Moriya, Kazuo Kobayashi, Naotake Ogasawara
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
Mol Microbiol: 2003, 49(4);1135-44
[PubMed:12890034]
[WorldCat.org]
[DOI]
(P p)
Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453]
[WorldCat.org]
[DOI]
(P p)
