abh

168

transcriptional regulator of transition state genes

Locus: BSU_14480

Molecular weight: 10.12 kDa

Isoelectric point: 5.75

Protein length: 92 aa

Gene length: 279 bp

Function: regulation of gene expression during the transition from growth to stationary phase

Product: transcriptional regulator

Essential: no

Synonyms: abh, ylxT, yzaA

Genomic Context

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List of homologs in different organisms, belongs to COG2002 (Galperin et al., 2021)

Gene

Coordinates: 1,517,865  1,518,143

Phenotypes of a mutant

• inactivation of ''abh results in sensitivity against beta-lactam antibiotics that can be restored by induction of slrR expression or by inactivation of the genes encoding major autolysins (lytC, lytF'') PubMed

The protein

Domains

• SpoVT-AbrB domain (aa 5-50) (according to UniProt)

Structure

• 2FY9 (PDB) (N-terminal DNA recognition domain)
• P39758 (AlphaFold)

Paralogous protein(s)

• AbrB
• SpoVT, (only the N-terminal domains (aa 1 through 50) are conserved between SpoVT and the two paralogues)

Expression and Regulation

Operons

• Genes: abh

  Description: PubMed

  Regulation

  • expression is reduced in a SigV mutant PubMed

  Sigma factors

  • SigX: sigma factor, PubMed, in sigX regulon
  • SigM: sigma factor, PubMed, in sigM regulon
  • SigV: sigma factor, in sigV regulon

Biological materials

Mutant

• BKE14480 (abh::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAAAAACCCTTCTTCCTT,  downstream forward: _UP4_TAAAATTATGCTAAAAAAGG
• BKK14480 (abh::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAAAAACCCTTCTTCCTT,  downstream forward: _UP4_TAAAATTATGCTAAAAAAGG

Labs working on this gene/protein

• Mark Strauch, Baltimore, USA homepage

References

Other original publications

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The Abh regulon

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