licC

168

lichenan-specific permease of the phosphotransferase system, EIIC of the PTS

Locus: BSU_38580

Molecular weight: 48.37 kDa

Isoelectric point: 8.58

Protein length: 452 aa

Gene length: 1359 bp

Function: lichenan uptake and phosphorylation

Product: lichenan-specific lichenan-specific PTS, EIIC component

Essential: no

Synonyms: licC, celB

Genomic Context

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List of homologs in different organisms, belongs to COG1455 (Galperin et al., 2021)

Gene

Coordinates: 3,960,192  3,961,550

The protein

Protein family

• PTS permease, lactose family PubMed

Domains

• PTS EIIC domain type-3 (aa 8-421) (according to UniProt)

Structure

• 3QNQ (PDB) (EIIC component of diacetylchitobiose specific PTS from Bacillus cereus; 60% identity, 87% similarity) PubMed
• P46317 (AlphaFold)

Paralogous protein(s)

• YwbA, GmuC

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: licB-licC-licA-licH

  Description: PubMed

  Regulation

  • carbon catabolite repression (CcpA) PubMed

  Regulatory mechanism

  • CcpA: repression, PubMed, in ccpA regulon
  • LicR: activation, PubMed, in licR regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• BKE38580 (licC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACATAGCCCGCCCCTCTCT,  downstream forward: _UP4_CTGTAGAGAAAGGAAGTGAA
• BKK38580 (licC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACATAGCCCGCCCCTCTCT,  downstream forward: _UP4_CTGTAGAGAAAGGAAGTGAA

References

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