trxB

168

thioredoxin reductase (NADPH)

Locus: BSU_34790

Molecular weight: 34.36 kDa

Isoelectric point: 4.99

Protein length: 316 aa

Gene length: 951 bp

Function: keeps Thioredoxin in the reduced state

Product: thioredoxin reductase (NADPH)

Essential: yes

E.C.: 1.8.1.9

Synonyms: trxB, yvcH, trxR

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0492 (Galperin et al., 2021)

Gene

Coordinates: 3,573,207  3,574,157

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• Thioredoxin + NADP⁺ --> Thioredoxin disulfide +  NADPH PubMed

Protein family

• class-II pyridine nucleotide-disulfide oxidoreductase family (with AhpF, according to UniProt)

Cofactors

• FAD PubMed

Structure

• 4GCM (PDB) (from S. aureus, 71% identity)
• P80880 (AlphaFold)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: trxB

  Description: PubMed

  Regulation

  • induced by cell wall stress (Spx) PubMed

  Regulatory mechanism

  • Spx: activation, PubMed, in spx regulon

References

Reviews

Loading

Original Publications

Loading