tpx

168

probable thiol peroxidase

Locus: BSU_29490

Molecular weight: 18.07 kDa

Isoelectric point: 4.7

Protein length: 167 aa

Gene length: 504 bp

Function: unknown

Product: unknown

Essential: no

Synonyms: tpx, ytgI

Genomic Context

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Categories containing this gene/protein

Lifestyles, Coping with stress, Resistance against oxidative and electrophile stress

List of homologs in different organisms, belongs to COG2077 (Galperin et al., 2021)

This gene is a member of the following regulons

Spx regulon

Gene

Coordinates: 3,017,696  3,018,199

The protein

Catalyzed reaction/ biological activity

[protein]-dithiol + hydroperoxide --> [protein]-disulfide + alcohol + H₂O (according to UniProt)

Protein family

peroxiredoxin family (according to UniProt)

Domains

Thioredoxin domain (aa 18-167) (according to UniProt)

Structure

2JSZ (PDB)
P80864 (AlphaFold)

Expression and Regulation

Operons

Genes: tpx-ytxK

Description: PubMed

Regulatory mechanism

Spx: activation, PubMed, in spx regulon

Genes: tpx

Description: PubMed

Regulatory mechanism

Spx: activation, PubMed, in spx regulon

Biological materials

Mutant

MGNA-A113 (ytgI::erm), available at the NBRP B. subtilis, Japan
BKE29490 (tpx::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTATAATTCCTCCCTTTT,  downstream forward: _UP4_TAAGCAGGGAAAAAAGCTCC
BKK29490 (tpx::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTATAATTCCTCCCTTTT,  downstream forward: _UP4_TAAGCAGGGAAAAAAGCTCC

References

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