ppiB

168

peptidyl-prolyl isomerase

Locus: BSU_23360

Molecular weight: 15.11 kDa

Isoelectric point: 5.47

Protein length: 143 aa

Gene length: 432 bp

Function: protein folding

Product: peptidyl-prolyl isomerase

Essential: no

E.C.: 5.2.1.8

Synonyms: ppiB, cypBS

Genomic Context

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List of homologs in different organisms, belongs to COG0652 (Galperin et al., 2021)

Gene

Coordinates: 2,435,360  2,435,791

The protein

Catalyzed reaction/ biological activity

• [protein]-peptidylproline (ω=180) --> [protein]-peptidylproline (ω=0) (according to UniProt)

Protein family

• cyclophilin-type PPIase family (single member, according to UniProt)

Domains

• PPIase cyclophilin-type domain (aa 1-143) (according to UniProt)

Structure

• 2MVZ (PDB) (from Geobacillus kaustophilus, 75% identity) PubMed
• P35137 (AlphaFold)

Expression and Regulation

Operons

• Genes: ppiB

  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• BKE23360 (ppiB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATTGTATGCCTACTTTCT,  downstream forward: _UP4_TAATCGGCAGGCAAAAGGCT
• BKK23360 (ppiB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATTGTATGCCTACTTTCT,  downstream forward: _UP4_TAATCGGCAGGCAAAAGGCT

References

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