nadC

nadC
168

nicotinate-nucleotide diphosphorylase (carboxylating)

Locus
BSU_27860
Molecular weight
31.24 kDa
Isoelectric point
5.18
Protein length
Gene length
Function
NAD biosynthesis
Product
nicotinate-nucleotide diphosphorylase (carboxylating)
Essential
no
E.C.
2.4.2.19
Synonyms
nadC, yrxB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0157 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,847,048  2,847,917
The protein
Catalyzed reaction/ biological activity
CO2 + diphosphate + nicotinate β-D-ribonucleotide --> 5-phospho-α-D-ribose 1-diphosphate + 2 H+ + quinolinate (according to UniProt)
Protein family
nadC/modD family (single member, according to UniProt)
Structure
1X1O (PDB) (from Thermus thermophilus, 45% identity)
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Description
Regulation
repressed in the presence of nicotinic acid (NadR) PubMed
Regulatory mechanism
NadR: repression, PubMed, in nadR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
An ncRNA is predicted for 'nadB' PubMed
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nadBnadA

2025-04-18 01:53:58

ghost

119

4f70dedfb39fe2edf4df8c48406b789cb6f009f0

0DADAB25BF759B1341F8AD45873BE220231A782F

Biological materials
Mutant
BKE27860 (nadC::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CCTCAAGAAAAAAGTGATTC,  downstream forward: _UP4_TGTTATGTCAATTCTTGATG
BKK27860 (nadC::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CCTCAAGAAAAAAGTGATTC,  downstream forward: _UP4_TGTTATGTCAATTCTTGATG
References
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1368734DCC28C618AA173B865784BDDAEA912623

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Time of last update: 2025-05-01 00:22:53

Author of last update: Melvin.boenninger