ftsA

168

cell division protein, membrane anchor for FtsZ

Locus: BSU_15280

Molecular weight: 47.94 kDa

Isoelectric point: 5.09

Protein length: 440 aa

Gene length: 1323 bp

Function: formation of Z-ring

Product: cell division protein, member of the divisome

Essential: no

Synonyms: ftsA, spoIIN

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0849 (Galperin et al., 2021)

Gene

Coordinates: 1,596,474  1,597,796

Phenotypes of a mutant

• cells become elongated PubMed
• the ''ftsA mutation is synthetically lethal with a sepF'' mutation PubMed

The protein

Catalyzed reaction/ biological activity

• required for septum recruitment of SftA PubMed

Protein family

• FtsA/MreB family (according to UniProt)

Structure

• 3WQT (PDB) (from Staphylococcus aureus, 31% identity) PubMed
• P28264 (AlphaFold)

Localization

• during vegetative growth: uniform FtsA-FtsZ rings around the leading edge of the invaginating medial septum to orchestrate cell division (FtsA is proximal to the membrane and tethers FtsZ) PubMed
• at the onset of sporulation: FtsA-FtsZ filaments are assembled only on the mother cell side of the invaginating polar septum, this depends on SpoIIE PubMed
• septal at the cell membrane (35% of the molecules) PubMed
• cytoplasma (65% of the molecules) PubMed
• septal localization depends on the proton motive force PubMed

Expression and Regulation

Operons

• Genes: ftsA-ftsZ

  Description: PubMed

  Regulation

  • activated by WalR PubMed

  Regulatory mechanism

  • WalR: activation, in walR regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon
  • SigH: sigma factor, PubMed, in sigH regulon

  Additional information

  • half-life of the ''ftsZ'' mRNA: 2.2 min PubMed

Biological materials

Mutant

• 1A787 ( ftsA::cat), PubMed, available at BGSC

References

Reviews

Loading

Original Publications

Loading