folB

168

dihydroneopterin aldolase

Locus: BSU_00780

Molecular weight: 13.38 kDa

Isoelectric point: 5.23

Protein length: 120 aa

Gene length: 363 bp

Function: biosynthesis of folate

Product: dihydroneopterin aldolase

Essential: yes

E.C.: 4.1.2.25

Synonyms: folB, folA, yacE

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG1539 (Galperin et al., 2021)

Gene

Coordinates: 86,587  86,949

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• 7,8-dihydroneopterin --> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde (according to UniProt)

Protein family

• DHNA family (single member, according to UniProt)

Structure

• 8SU7 (PDB) (from B. anthracis, 63% identity)
• 1U68 (PDB) (from Staphylococcus aureus, 47% identity, 72% similarity) PubMed
• P28823 (AlphaFold)

Expression and Regulation

Operons

• Genes: pabB-pabA-pabC-sul-folB-folK-yazB-dusB1-lysS

  Description: PubMed

  Regulation

  • translation repressed by tryptophan (MtrB) PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

References

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