yhdL

168

anti-SigM factor, with YhdK, responds to the free pool of the carrier lipid undecaprenyl-phosphate

Locus: BSU_09510

Molecular weight: 40.42 kDa

Isoelectric point: 6.18

Protein length: 358 aa

Gene length: 1077 bp

Function: control of SigM activity

Product: anti-SigM protein

Essential: yes

Synonyms: yhdL

Genomic Context

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List of homologs in different organisms

Gene

Coordinates: 1,028,511  1,029,587

Phenotypes of a mutant

• essential PubMed
• essentiality is suppressed by a YidC1 gain-of-function mutation (Q140K) present in B. subtilis strain PY97 PubMed

The protein

Structure

• O07581 (AlphaFold)

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: sigM-yhdL-yhdK

  Description: PubMed

  Regulation

  • induced by glucose PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon
  • SigM: sigma factor, PubMed, in sigM regulon

  Additional information

  • expression of CsbB in the absence of YfhO causes constitutive activation of SigM PubMed

Biological materials

Mutant

• MGNA-B482 (yhdL::erm), available at the NBRP B. subtilis, Japan
• BP97 (Δ(sigM-yhdL-yhdK)::aphA3), available in Fabian Commichau's lab

References

Reviews

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Original Publications

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