pyrG

168

CTP synthase (NH₃, glutamine)

Locus: BSU_37150

Molecular weight: 59.55 kDa

Isoelectric point: 5.16

Protein length: 535 aa

Gene length: 1608 bp

Function: pyrimidine biosynthesis

Product: CTP synthase (NH3, glutamine)

Essential: yes

E.C.: 6.3.4.2

Synonyms: pyrG, ctrA

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0504 (Galperin et al., 2021)

Gene

Coordinates: 3,810,693 → 3,812,300

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + H₂O + L-glutamine + UTP --> ADP + CTP + 2 H⁺ + L-glutamate + phosphate (according to UniProt)

Protein family

• CTP synthase family (single member, according to UniProt)

Domains

• Glutamine amidotransferase type-1 domain (aa 292-534) (according to UniProt)

Structure

• 1VCM (PDB) (from Thermus thermophilus, 52% identity, 70% similarity) PubMed
• P13242 (AlphaFold)

Expression and Regulation

Operons

• Genes: rpoE-pyrG

  Description: PubMed

  Regulation

  • the mRNA is processed between rpoE and pyrG by RNase Y, this requires the RicA-RicF-RicT complex PubMed

• Genes: pyrG

  Description: PubMed

  Regulation

  • repressed by cytidine nucleotides (RNA switch) PubMed

  Regulatory mechanism

  • RNA switch: RNA switch, in RNA switch

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Additional information

• the mRNA is cleaved by RNase III PubMed

References

Reviews

Loading

Original Publications

Loading