resC

168

part of heam translocase, required for cytochrome c synthesis

Locus: BSU_23130

Molecular weight: 39.61 kDa

Isoelectric point: 9.56

Protein length: 391 aa

Gene length: 1176 bp

Function: cytochrome c biogenesis

Product: part of the ResB-ResC haem translocase

Essential: no

Synonyms: resC, ypxC

Genomic Context

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List of homologs in different organisms, belongs to COG0755 (Galperin et al., 2021)

Gene

Coordinates: 2,417,984  2,419,159

Phenotypes of a mutant

• essential PubMed, non-essential according to PubMed

The protein

Catalyzed reaction/ biological activity

• haem-binding protein,  translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane PubMed

Protein family

• CcmF/CycK/Ccl1/NrfE/CcsA family (single member, according to UniProt)

Structure

• P35162 (AlphaFold)

Localization

• cytoplasma membrane PubMed

Expression and Regulation

Operons

• Genes: rluB-resA-resB-resC-resD-resE

  Description: PubMed

• Genes: resA-resB-resC-resD-resE

  Description: PubMed

  Regulation

  • expressed under anaerobic conditions (ResD) PubMed

  Regulatory mechanism

  • ResD: activation, PubMed, in resD regulon
  • PhoP: activation, PubMed, in phoP regulon
  • CcpA: repression, PubMed, in ccpA regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• BKE23130 (resC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TGCCATGACATCACTCCCTT,  downstream forward: _UP4_TAGTCCTTTGAAAGCGACAC
• BKK23130 (resC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TGCCATGACATCACTCCCTT,  downstream forward: _UP4_TAGTCCTTTGAAAGCGACAC

References

Reviews

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Original Publications

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