atpH

atpH
168

ATP synthase, part of the F1 complex (subunit delta)

Locus
BSU_36840
Molecular weight
19.84 kDa
Isoelectric point
9.57
Protein length
Gene length
Function
ATP synthesis
Product
ATP synthase (subunit delta)
Essential
no
Synonyms
atpH

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0712 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,785,403 → 3,785,948
The protein
Catalyzed reaction/ biological activity
ATP synthesis see a video
Protein family
ATPase delta chain family (single member, according to UniProt)
Structure
5T4O (PDB) (ATPase from E. coli, 25% identity) PubMed
Modification
phosphorylated on Arg-159 PubMed
Effectors of protein activity
ATPase activity is inhibited upon binding of Mg-ADP to AtpD PubMed
membrane (Heterogeneous) PubMed
peripheral via the F0 complex
http://subtiwiki.uni-goettingen.de/v3/gene/view/E956A30D97B2941108880F3AD48620C4DB6E0EBD
Expression and Regulation
Operons
Description
Regulation
Rel dependent downregulation (Class I) during stringent response PubMed
the mRNA is processed between atpI and atpB by RNase Y, this requires the RicA-RicF-RicT complex PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
Open in new tab

atpIatpC

2025-06-22 05:29:25

Jstuelk

149

c30b9914547f38015d481b305686327f4f8f18d8

1C7DF7F5F812B06EFE55424A9900C106B30D346A

Biological materials
Mutant
BKE36840 (ΔatpH::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_TCGTTTAGAGACAGCTGATC,  downstream forward: _UP4_AATCGATAGAAGGGGTGAAA
BKK36840 (ΔatpH::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_TCGTTTAGAGACAGCTGATC,  downstream forward: _UP4_AATCGATAGAAGGGGTGAAA
References
Reviews
Walker JE The ATP synthase: the understood, the uncertain and the unknown. Biochemical Society transactions. 2013 Feb 01; 41(1):1-16. doi:10.1042/BST20110773. PMID:23356252
Iino R, Noji H Operation mechanism of F(o) F(1)-adenosine triphosphate synthase revealed by its structure and dynamics. IUBMB life. 2013 Mar; 65(3):238-46. doi:10.1002/iub.1120. PMID:23341301
Sielaff H, Börsch M Twisting and subunit rotation in single F(O)(F1)-ATP synthase. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2013 Feb 05; 368(1611):20120024. doi:10.1098/rstb.2012.0024. PMID:23267178
Senior AE Two ATPases. The Journal of biological chemistry. 2012 Aug 31; 287(36):30049-62. doi:10.1074/jbc.X112.402313. PMID:22822068
Okuno D, Iino R, Noji H Rotation and structure of FoF1-ATP synthase. Journal of biochemistry. 2011 Jun; 149(6):655-64. doi:10.1093/jb/mvr049. PMID:21524994
von Ballmoos C, Wiedenmann A, Dimroth P Essentials for ATP synthesis by F1F0 ATP synthases. Annual review of biochemistry. 2009; 78:649-72. doi:10.1146/annurev.biochem.78.081307.104803. PMID:19489730
Weber J ATP synthase--the structure of the stator stalk. Trends in biochemical sciences. 2007 Feb; 32(2):53-6. . PMID:17208001
Weber J ATP synthase: subunit-subunit interactions in the stator stalk. Biochimica et biophysica acta.; 1757(9-10):1162-70. . PMID:16730323
Original Publications
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E956A30D97B2941108880F3AD48620C4DB6E0EBD

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Time of last update: 2025-06-23 11:43:44

Author of last update: Jstuelk