rplS

168

ribosomal protein bL19

Locus: BSU_16040

Molecular weight: 13.61 kDa

Isoelectric point: 11.29

Protein length: 118 aa

Gene length: 357 bp

Function: translation

Product: ribosomal protein L19 (bL19)

Essential: yes

Synonyms: rplS

Genomic Context

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List of homologs in different organisms, belongs to COG0335 (Galperin et al., 2021)

Gene

Coordinates: 1,676,033  1,676,389

Phenotypes of a mutant

• essential PubMed

The protein

Protein family

• bacterial ribosomal protein bL19 family (single member, according to UniProt)

Structure

• 3J9W (PDB) (the ribosome) PubMed
• O31742 (AlphaFold)

Additional information

• this ribosomal protein is lacking in some organisms with very small genomes PubMed

Expression and Regulation

Operons

• Genes: ylxM-ffh-rpsP-khpA-ylqD-rimM-trmD-rplS

  Description: PubMed

  Regulation

  • the mRNA is processed between ffh and rpsP by RNase Y, this requires the RicA-RicF-RicT complex PubMed

  Expression

  • expression is decreased upon depletion of tRNA maturation factors rnpB or rnz PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

• Genes: rplS

  Description: PubMed

  Regulation

  • likely autorepression of rplS expression upon binding of excess RplS to the untranslated region of the rplS mRNA PubMed
  • Rel dependent downregulation (Class I) during stringent response PubMed

  Regulatory mechanism

  • stringent response: negative regulation, in stringent response

• Genes: rpsP-khpA-ylqD-rimM-trmD-rplS

  Description: PubMed

References

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