frr

168

ribosome recycling factor, catalyzes the dissociation of ribosome subunits following peptide chain release in translation termination

Locus: BSU_16520

Molecular weight: 20.62 kDa

Isoelectric point: 5.33

Protein length: 185 aa

Gene length: 558 bp

Function: translation

Product: ribosome recycling factor

Essential: yes

Synonyms: frr

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0233 (Galperin et al., 2021)

Gene

Coordinates: 1,720,526  1,721,083

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• catalyzes the dissociation of ribosome subunits following peptide chain release in translation termination PubMed

Protein family

• RRF family (single member, according to UniProt)

Structure

• 4GFQ (PDB) (from B. anthracis, 75% identity)
• P81101 (AlphaFold)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: rpsB-tsf-pyrH-frr

  Description: PubMed

  Regulation

  • Rel dependent downregulation (Class I) during stringent response PubMed

  Regulatory mechanism

  • stringent response: negative regulation, PubMed, in stringent response

References

Reviews

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Original Publications

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