dapB

168

dihydrodipicolinate reductase (NADPH)

Locus: BSU_22490

Molecular weight: 29.34 kDa

Isoelectric point: 5.06

Protein length: 267 aa

Gene length: 804 bp

Function: biosynthesis of lysine and peptidoglycan

Product: dihydrodipicolinate reductase (NADPH)

Essential: yes

E.C.: 1.3.1.26

Synonyms: dapB

Genomic Context

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List of homologs in different organisms, belongs to COG0289 (Galperin et al., 2021)

Gene

Coordinates: 2,359,340  2,360,143

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• (S)-2,3,4,5-tetrahydrodipicolinate + H₂O + NAD⁺ --> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H⁺ + NADH (according to UniProt)
• (S)-2,3,4,5-tetrahydrodipicolinate + H₂O + NADP⁺ --> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H⁺ + NADPH (according to UniProt)

Protein family

• DapB family (single member, according to UniProt)

Cofactors

• NADP⁺

Structure

• 1YL6 (PDB) (from Mycobacterium tuberculosis, 46% identity, 67% similarity) PubMed
• P42976 (AlphaFold)

Expression and Regulation

Operons

• Genes: ypjD-dapB-mgsA-bshB1-bshA-cca-birA

  Description: PubMed

  Regulation

  • induced by diamide stess (thiol depletion) (Spx) PubMed

  Regulatory mechanism

  • Spx: activation, PubMed, in spx regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

References

Operon and expression

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