feuA
168
ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein), with YusV as ATPase
Locus
BSU_01630
Molecular weight
34.95 kDa
Isoelectric point
8.02
Function
Product
ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein) PubMed
Essential
no
Synonyms
feuA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0614 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
182,370 183,323
Phenotypes of a mutant
severe growth inhibition upon addition of subinhibitory concentrations of mirubactin C PubMed
The protein
Protein family
Bacterial solute-binding protein 8 family (according to UniProt)
Two independent non-symmetric globular domains, connected by a long alpha-helix (residues 143-164 of the mature protein).
Fe/B12 periplasmic-binding domain (aa 57-317) (according to UniProt)
Structure
2XUZ (PDB) (complex with ferri-enterobactin)
2XV1 (PDB) (complex with ferric mecam)
Modification
FeuA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure PubMed
Expression and Regulation
Operons
Description
Regulation
expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
Regulatory mechanism
Btr: activation, in the presence of the co-activators bacillibactin or enterobactin PubMed, in btr regulon
Sigma factors
Additional information
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Other regulations
CitB: translation control
Biological materials
Mutant
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab
References
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Time of last update: 2024-12-21 13:34:57
Author of last update: Jstuelk