ywhA

168

similar to transcriptional regulator (MarR family)

Locus: BSU_37550

Molecular weight: 15.73 kDa

Isoelectric point: 8.14

Protein length: 139 aa

Gene length: 420 bp

Function: unknown

Product: unknown

Essential: no

Synonyms: ywhA

Genomic Context

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List of homologs in different organisms, belongs to COG1846 (Galperin et al., 2021)

Gene

Coordinates: 3,853,717  3,854,136

The protein

Domains

• HTH marR-type domain (aa 8-139) (according to UniProt)

Structure

• P70993 (AlphaFold)

Expression and Regulation

Operons

• Genes: thrZ-ywhA

  Description: PubMed

  Regulation

  • induced by threonine limitation (T-box) PubMed
  • the T-box RNA is degraded by RNase Y PubMed

  Regulatory mechanism

  • T-box: RNA switch, in T-box

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• MGNA-A517 (ywhA::erm), available at the NBRP B. subtilis, Japan
• BKE37550 (ywhA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTCAATTTCCCCATTTC,  downstream forward: _UP4_TAGGGATAATAAAAGCCGGT
• BKK37550 (ywhA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTCAATTTCCCCATTTC,  downstream forward: _UP4_TAGGGATAATAAAAGCCGGT

References

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