ResA

• Description: extracytoplasmic thioredoxin, cytochrome c biogenesis, reduces disulfide bonds in apo-cytochrome prior to the attachment of heme
  
  

Gene name	resA
Synonyms	ypxA
Essential	no
Product	extracytoplasmic thioredoxin
Function	cytochrome c biogenesis
Gene expression levels in SubtiExpress: resA
Metabolic function and regulation of this protein in SubtiPathways: ResA
MW, pI	20 kDa, 8.37
Gene length, protein length	543 bp, 181 aa
Immediate neighbours	resB, rluB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

respiration

This gene is a member of the following regulons

CcpA regulon, PhoP regulon, ResD regulon

The gene

Basic information

• Locus tag: BSU23150

Phenotypes of a mutant

• essential according to Kobayashi et al., but inactivation of resA was reported by Erlendsson et al.

Database entries

• BsubCyc: BSU23150

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ResA subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU23150

• Structure: 3C73

• UniProt: P35160

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: resA-resB-resC-resD-resE PubMed

• Expression browser: resA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under anaerobic conditions (ResD) PubMed
  • expressed under conditions of phosphate limitation (PhoP) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • ResD: transcription activation PubMed
  • PhoP: transcription activation PubMed
  • CcpA: transcription repression PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 119 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 213 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

• Additional publications

PubMed