ygaF

168

similar to thioredoxin-dependent hydroperoxide peroxidase

Locus: BSU_08720

Molecular weight: 17.97 kDa

Isoelectric point: 5.86

Protein length: 157 aa

Gene length: 474 bp

Function: resistance against oxidative stress

Product: unknown

Essential: no

Synonyms: ygaF

Genomic Context

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List of homologs in different organisms, belongs to COG1225 (Galperin et al., 2021)

Gene

Coordinates: 943,891  944,364

The protein

Catalyzed reaction/ biological activity

• [protein]-dithiol + hydroperoxide --> [protein]-disulfide + alcohol + H₂O (according to UniProt)

Protein family

• peroxiredoxin family (according to UniProt)

Domains

• Thioredoxin domain (aa 3-156) (according to UniProt)

Structure

• 5ENU (PDB) (from Burkholderia ambifaria, 48% identity)
• Q796Y8 (AlphaFold)

Expression and Regulation

Operons

• Genes: ygaF-perR

  Description: PubMed

Biological materials

Mutant

• BKE08720 (ygaF::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTACGTTACCTCCGGATG,  downstream forward: _UP4_TAAATCTCTATGAGCCTATG
• BKK08720 (ygaF::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTACGTTACCTCCGGATG,  downstream forward: _UP4_TAAATCTCTATGAGCCTATG

References

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