purE
168
phosphoribosylaminoimidazole carboxylase (ATP-dependent)
Locus
BSU_06420
Molecular weight
17.03 kDa
Isoelectric point
5.2
Function
purine biosynthesis
Product
phosphoribosylaminoimidazole carboxylase (ATP-dependent)
Essential
no
E.C.
4.1.1.21
Synonyms
purE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0041 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
698,612 699,100
The protein
Catalyzed reaction/ biological activity
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H+ --> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate (according to UniProt)
Protein family
AIR carboxylase family ( single member, according to UniProt)
Structure
1O4V (PDB) (from Thermotoga maritima, 53% identity, 64% similarity) PubMed
Expression and Regulation
Operons
Description
Regulation
expression activated by glucose (4.4 fold) PubMed
Regulatory mechanism
Sigma factors
Open in new tab
Biological materials
Mutant
References
Loading
Page visits: 5403
Time of last update: 2025-07-17 22:14:45
Author of last update: Jstuelk